Dietary Supplement "Folate" Life Extensions Optimized Folate

Folic acid must be in its active form to be properly absorbed by our body. This biochemical process occurs in the intestines and liver. Some enzymes may be absent in the body or very weakly convert folic acid into its active form, 5-MTHF. Therefore, taking 5-MTHF as Metafolin is an effective method. 5-MTHF is a necessary cofactor in the metabolism of homocysteine, and is also essential for the normal production of neurotransmitters such as serotonin, melatonin, dopamine, adrenaline, and norepinephrine. This makes Metafolin critically important both for the cardiovascular system and for mood support, treating depression, and dementia.

During pregnancy, low levels of folic acid in the body are linked to neural tube defects in the fetus, miscarriage, lower birth weight, and various developmental complications.